Products
Tetramethylammonium chloride
Synonyms:Tetramethylammonium chloride
Chemical Property of Tetramethylammonium Chloride
● Appearance/Colour:white crystals
● Vapor Pressure:3965.255mmHg at 25°C
● Melting Point:>300 °C(lit.)
● Refractive Index:1.5320 (estimate)
● Boiling Point:165.26°C (rough estimate)
● PSA：0.00000
● Density:1.17 g/cm3
● LogP:-2.67360
● Storage Temp.:Store at RT.
● Sensitive.:Hygroscopic
● Solubility.:methanol: 0.1 g/mL, clear, colorless
● Water Solubility.:>60 g/100 mL (20 ºC)
● Hydrogen Bond Donor Count:0
● Hydrogen Bond Acceptor Count:1
● Rotatable Bond Count:0
● Exact Mass:109.0658271
● Heavy Atom Count:6
● Complexity:23
Safty Information
● Pictogram(s):
T, 
Xn
● Hazard Codes:T,Xn
● Statements:21-25-36/37/38-20/21/22
● Safety Statements:26-36/37-45-37/39-28A-28-36
Useful
Canonical SMILES:C[N+](C)(C)C.[Cl-]
Uses:1. It can be used as polarographic analysis reagents which is widely used in the electronics industry.
2. Tetramethylammonium chloride is the phase transfer catalyst in organic synthesis with its catalytic activity being stronger than triphenylphosphine and triethylamine. At room temperature, it is a white crystalline powder, and is volatile, irritant, and easy to absorb moisture. It is easily soluble in methanol, soluble in water and hot ethanol but insoluble in ether and chloroform. Being heated to above 230 °C causes its decomposition into trimethylamine and methyl chloride. Median lethal dose (mice, intraperitoneal) is around 25mg/kg. It is also used for the synthesis of liquid crystal epoxy compound, and Pope and polarographic analysis, as well as electronic industry. Chemical intermediate, catalyst, inhibitor. Tetramethylammonium chloride along with N-hydroxyphthalimide and xanthone may be used as an efficient chloride catalytic system for the aerobic oxidation of hydrocarbons to form the corresponding oxygenated compounds. It may also be used as a phase transfer catalyst for the synthesis of aryl fluorides via selective chloride/fluoride exchange reaction of activated aryl chlorides with potassium fluoride in solid-liquid phase. TMAC may be used in ion-exchange procedures to show the increase of pH in understanding the chemical behaviour of catalyst [CTA]Si-MCM-41 using Knoevenagel condensation model.
Detailed Introduction
Tetramethylammonium chloride, also known as TMAC or TMA chloride, is a quaternary ammonium salt. It is composed of a central nitrogen atom bonded to four methyl groups and a chloride ion. This compound has a molecular formula of (CH3)4NCl.
TMAC is a white crystalline solid with a characteristic odor. It is highly soluble in water and has a low melting point, making it easily accessible and practical for various applications.
Application
Tetramethylammonium chloride (TMAC) has several applications in various industries. Some notable applications include:
Catalyst and reagent: TMAC is commonly used as a phase transfer catalyst in organic synthesis. It enables reactions between immiscible solvents by facilitating the transfer of reactants and ions across the phases. It is particularly useful in reactions such as nucleophilic substitution and Quaternary ammonium salt formation.
Surfactant: TMAC acts as a surfactant, reducing surface tension and improving the wetting and dispersing properties of liquids. It finds applications in the formulation of detergents, adhesives, coatings, and emulsions.
Electrochemical applications: TMAC is used as an electrolyte additive in batteries and fuel cells to enhance their performance and stability. It assists in maintaining the ionic balance and conductivity within the cells.
Ion chromatography: TMAC is used as a reference standard in ion chromatography to help analyze and separate different analytes based on their ionic properties. It aids in determining the concentrations of various ions in liquid samples.
Capillary electrophoresis: TMAC can serve as an electrolyte in capillary electrophoresis, where it helps in separating and analyzing charged particles based on their mobility and charge.
Environmental research: TMAC is employed in environmental studies to investigate ion interactions, transport, and partitioning in various systems. It is especially significant in understanding the behavior of organic pollutants and studying their fate in different environments.
These are just a few examples of the applications of tetramethylammonium chloride. Its versatile properties make it valuable in various fields, such as organic synthesis, electrochemistry, analytical chemistry, and environmental research.
