Products
N-Methyl-2-pyrrolidone
Synonyms:1-methyl-2-pyrrolidinone;1-methyl-2-pyrrolidinone, 1-methyl-(14)C-labeled;1-methyl-2-pyrrolidinone, 2,3,4,5-(14)C-labeled;methyl pyrrolidone;N-methyl-2-pyrrolidinone;N-methyl-2-pyrrolidone;N-methylpyrrolidinone;N-methylpyrrolidone;pharmasolve
Chemical Property of N-Methyl-2-Pyrrolidone
● Appearance/Colour:colourless or light yellow liquid with an amine odour
● Vapor Pressure:0.29 mm Hg ( 20 °C)
● Melting Point:-24 °C
● Refractive Index:n20/D 1.479
● Boiling Point:201.999 °C at 760 mmHg
● PKA:-0.41±0.20(Predicted)
● Flash Point:86.111 °C
● PSA：20.31000
● Density:1.033
● LogP:0.17650
● Storage Temp.:2-8°C
● Sensitive.:Hygroscopic
● Solubility.:ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)
● Water Solubility.:>=10 g/100 mL at 20 ºC
● XLogP3:-0.5
● Hydrogen Bond Donor Count:0
● Hydrogen Bond Acceptor Count:1
● Rotatable Bond Count:0
● Exact Mass:99.068413911
● Heavy Atom Count:7
● Complexity:90.1
● Transport DOT Label:Combustible Liquid
Safty Information
● Pictogram(s):
T,
Xi
● Hazard Codes:T,Xi
● Statements:45-65-36/38-36/37/38-61-10-46
● Safety Statements:41-45-53-62-26
Useful
Chemical Classes:Solvents -> Other Solvents
Canonical SMILES:CN1CCCC1=O
Recent ClinicalTrials:NMP in Relapsed / Refractory Myeloma
Inhalation Risk:A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.
Effects of Short Term Exposure:The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. Exposure to very high concentrations could cause lowering of consciousness.
Effects of Long Term Exposure:Repeated or prolonged contact with skin may cause dermatitis. Animal tests show that this substance possibly causes toxic effects upon human reproduction.
Detailed Introduction
N-Methyl-2-pyrrolidone (NMP) is a clear, colorless liquid with a slightly sweet odor. It is an organic compound with the chemical formula C5H9NO. NMP is miscible with water and most organic solvents, making it a versatile solvent in various industries.
NMP has a high boiling point of around 202-204°C (396-399°F) and a low vapor pressure, which makes it useful in processes that require high-temperature stability. It has a relatively low viscosity and good solvency power, enabling it to dissolve a wide range of materials including polymers, resins, and other organic compounds.
NMP is highly polar, making it an excellent solvent for polar substances. It has a dipole moment of 3.78 Debye, which allows it to solvate and stabilize charged species. This property makes NMP suitable for use in many chemical reactions, as it can facilitate dissolution and reaction rates.
It is important to note that NMP has some health and safety considerations. It can be absorbed through the skin and inhalation of its vapors may cause irritation to the respiratory system. Long-term or repeated exposure to NMP may have adverse effects on fertility and the development of the fetus in pregnant women. Consequently, proper safety precautions and guidelines should be followed when handling and using NMP.
Application
N-Methyl-2-pyrrolidone (NMP) is a solvent commonly used in various industries. Here are some applications of NMP:
Pharmaceuticals: NMP is used as a solvent in the pharmaceutical industry for the formulation of drug products. It can dissolve a wide range of active pharmaceutical ingredients (APIs) and excipients, making it suitable for drug formulation processes such as drug synthesis, formulation development, and drug delivery systems.
Industrial Cleaning: NMP is a highly effective solvent for removing various types of contaminants, such as oils, greases, and resins. It is commonly used in industrial cleaning applications, including degreasing and cleaning of metal surfaces, machinery, and electronic components.
Paints and Coatings: NMP is used as a solvent in the formulation of paints, coatings, and varnishes. It helps dissolve resins and other components, improves the flow and leveling properties of the coating, and enhances the adhesion to the substrate.
Polymer Processing: NMP is used in polymer processing as a solvent for various polymers, including polyvinylidene fluoride (PVDF), polyurethane (PU), and polyvinyl chloride (PVC). It is used in processes such as spinning, casting, and film formation.
Electronics: NMP is used in the electronics industry for cleaning and degreasing electronic components, such as semiconductors, printed circuit boards, and connectors. It can effectively remove flux residues, soldering pastes, and other contaminants without damaging sensitive electronic components.
Agrochemicals: NMP is used as a solvent in the formulation of agrochemicals, including herbicides, insecticides, and fungicides. It helps in dissolving the active ingredients and other components, ensuring proper dispersion and effective application of the agrochemicals.
Lithium-Ion Batteries: NMP is used as a solvent for electrode preparation and electrolyte formulation in lithium-ion batteries. It helps dissolve and stabilize the lithium salts and other electrolyte components, ensuring the proper functioning of the battery.
It is important to note that NMP should be used with caution and proper safety measures due to its potential health and environmental hazards. It is advisable to follow the specific guidelines and regulations set by local authorities and industry standards when using NMP.
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