Products
DL-4-Chlorophenylglycine
Synonyms:6212-33-5;2-amino-2-(4-chlorophenyl)acetic acid;DL-4-Chlorophenylglycine;DL-2-(4-Chlorophenyl)glycine;Amino(4-chlorophenyl)acetic acid;Amino-(4-chloro-phenyl)-acetic acid;4-chlorophenylglycine;DL-(4-Chlorophenyl)glycine;(+/-)-4-Chlorophenylglycine;2-(4-Chlorophenyl)glycine;MFCD00049328;BENZENEACETIC ACID, ALPHA-AMINO-4-CHLORO-;CHEMBL133182;Benzeneacetic acid, .alpha.-amino-4-chloro-;L-4-Chlorophenylglycine;4-chloro-dl-phenylglycine;MFCD03701467;MFCD03839815;h-dl-phg(4-cl)-oh;methylN-carbamoylmaleamate;RM2JW43TGA;2-(p-chlorophenyl)glycine;DL-2-(4-Chlorophenyl );4-Chloro-DL-2-phenylglycine;dl-2-(p-Chlorophenyl)glycine;SCHEMBL390594;(4-Chlorophenyl)glycine, DL-;DTXSID40863712;Amino(4-chlorophenyl)acetic acid #;BCP25773;BBL022163;BDBM50179705;p-chloro-alpha-aminophenylacetic acid;STK130690;AKOS000189147;AKOS016051256;alpha-Amino-4-chlorobenzeneacetic acid;7L-304S;AB02094;AB15770;AB16238;AB88361;Benzeneacetic acid, a-amino-4-chloro-;CS-W002237;HY-W002237;DL-alpha-Amino-4-chlorophenylacetic Acid;SY017756;SY034115;SY034129;AM20060793;BB 0249643;FT-0600927;FT-0625383;FT-0630025;FT-0680568;EN300-88024;(+/-)-4-Chlorophenylglycine, >=98.0% (TLC);Q-102258;F2147-0645;Z317024646;(+/-)-4-CHLOROPHENYLGLYCINE 4-CHLOROPHENYL GLYCINE AMINO-(4-CHLORO-PHENYL)-ACETIC ACID (+/-)-ALPHA-AMINO-4-CHLOROPHENYLACETIC ACID
Chemical Property of DL-4-Chlorophenylglycine
● Appearance/Colour:white to light yellow crystal powder
● Vapor Pressure:7.45E-05mmHg at 25°C
● Melting Point:220-230 °C
● Refractive Index:1.603
● Boiling Point:328.8 °C at 760 mmHg
● PKA:1.81±0.10(Predicted)
● Flash Point:152.7 °C
● PSA：63.32000
● Density:1.392 g/cm3
● LogP:2.12470
● Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
● Solubility.:Soluble in 0.1mol/L NaOH (almost transparency).
● XLogP3:-1.1
● Hydrogen Bond Donor Count:2
● Hydrogen Bond Acceptor Count:3
● Rotatable Bond Count:2
● Exact Mass:185.0243562
● Heavy Atom Count:12
● Complexity:166
Safty Information
● Pictogram(s):
Xn
● Hazard Codes:Xn
● Statements:22-36/37/38
● Safety Statements:26-36
Useful
Canonical SMILES:C1=CC(=CC=C1C(C(=O)O)N)Cl
Uses:It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Detailed Introduction
2-Amino-2-(4-chlorophenyl)acetic acid is also known by its chemical name, 4-Chloro-alpha-aminobenzeneacetic acid. It is a white crystalline powder with a molecular formula of C8H8ClNO2 and a molecular weight of 185.61 g/mol.
Here are some additional details about 2-Amino-2-(4-chlorophenyl)acetic acid:
Synthesis: This compound can be synthesized through various methods, including the reaction of 4-Chloroacetophenone with glycine in the presence of a reducing agent like sodium borohydride, or by the reaction of 4-Chlorophenacyl bromide with sodium glycinate.
Physical and Chemical Properties:
1.Melting Point: The melting point of 2-Amino-2-(4-chlorophenyl)acetic acid is typically around 135-140 °C.
2.Solubility: It is sparingly soluble in water, but dissolves well in organic solvents such as ethanol and methanol.
3.pH: In aqueous solution, this compound is weakly acidic with a pH around 5-6.
Biological Properties:
1.Pharmacological Activities: Although there is limited information available on the pharmacological activities of 2-Amino-2-(4-chlorophenyl)acetic acid, some studies suggest that it may have potential anti-inflammatory and analgesic properties.
2.Metabolism: The metabolic fate of this compound in humans is not well-documented. However, it is expected to undergo enzymatic breakdown and elimination from the body.
Safety Considerations:
1.While 2-Amino-2-(4-chlorophenyl)acetic acid is generally considered to have low toxicity, it is recommended to handle it with caution and follow appropriate safety measures when handling or working with this compound.
2.It is important to wear protective equipment, such as gloves and goggles, and ensure proper ventilation when working with this substance.
3.Always refer to safety data sheets (SDS) and consult relevant safety guidelines and regulations when handling and using this compound.
Remember, the information provided here is a general overview and should not be considered as comprehensive or exhaustive. For specific applications or purposes, it is always recommended to consult specialized literature or trusted sources for detailed information.
Application
2-Amino-2-(4-chlorophenyl)acetic acid, also known as 4-Chloro-alpha-aminobenzeneacetic acid, has potential applications in various fields. Here are some possible applications:
Pharmaceutical Industry:
1.Drug synthesis: It can be used as a building block or intermediate in the synthesis of pharmaceutical compounds such as analgesics, anti-inflammatory drugs, or anti-bacterial agents.
2.Prodrug development: 2-Amino-2-(4-chlorophenyl)acetic acid may be used to develop prodrugs, which are inactive or less active forms of drugs that are converted to the active form in the body. This can help improve drug efficacy, bioavailability, or reduce side effects.
Chemical Research:
1.Organic synthesis: The compound can be used in the laboratory for organic synthesis reactions, particularly in the synthesis of complex organic compounds.
2.Ligand synthesis: It may be utilized for the preparation of ligands for coordination chemistry or catalysts for various chemical reactions.
Agricultural Industry:
1.Pesticide development: 2-Amino-2-(4-chlorophenyl)acetic acid can be used to synthesize new pesticides or herbicides that offer improved efficacy or reduced environmental impact.
Research and Development:
1.Chemical research: This compound may be used as a standard or reference compound for analytical purposes and method development in research laboratories.
2.Biological research: It can be used in studies investigating the role of amines and their derivatives in various physiological or biochemical pathways.
Please note that the specific applications and uses of 2-Amino-2-(4-chlorophenyl)acetic acid may depend on further research and development. Always consult scientific literature, regulatory requirements, and appropriate professionals before using or considering its application in a specific field.
