Products
4-Hydroxy-D-(-)-2-phenylglycine
Synonyms:(R,S)-3HPG;4-hydroxyphenylglycine;4-hydroxyphenylglycine hydrobromide, (+-)-isomer;4-hydroxyphenylglycine hydrochloride, (R)-isomer;4-hydroxyphenylglycine perchlorate, (+-)-isomer;4-hydroxyphenylglycine, (+-)-isomer;4-hydroxyphenylglycine, (R)-isomer;4-hydroxyphenylglycine, (S)-isomer;4-hydroxyphenylglycine, 2,4-dimethylbenzenesulfonate, (+-)-isomer;4-hydroxyphenylglycine, 2,4-dimethylbenzenesulfonate, (R)-isomer;4-hydroxyphenylglycine, 4-methylbenzenesulfonate, (+-)-isomer;4-hydroxyphenylglycine, 4-methylbenzenesulfonate, (S)-isomer;4-hydroxyphenylglycine, monosodium salt;4-hydroxyphenylglycine, monosodium salt, (R)-isomer;D-p-hydroxyphenylglycine;L-4-hydroxyphenylglycine;oxfenicine;p-hydroxyphenylglycine;UK 25842;UK-25842
Chemical Property of D(-)-4-Hydroxyphenylglycine
● Appearance/Colour:off-white powder
● Vapor Pressure:0.000272mmHg at 25°C
● Melting Point:240 °C (dec.)(lit.)
● Refractive Index:-158 ° (C=1, 1mol/L HCl)
● Boiling Point:365.8 °C at 760 mmHg
● PKA:2.15±0.10(Predicted)
● Flash Point:175 °C
● PSA：83.55000
● Density:1.396 g/cm3
● LogP:1.17690
● Storage Temp.:Store below +30°C.
● Solubility.:5g/l
● Water Solubility.:5 g/L (20 ºC)
● XLogP3:-2.1
● Hydrogen Bond Donor Count:3
● Hydrogen Bond Acceptor Count:4
● Rotatable Bond Count:2
● Exact Mass:167.058243149
● Heavy Atom Count:12
● Complexity:164
Safty Information
● Pictogram(s):
Xi
● Hazard Codes:Xi
● Statements:36/37/38
● Safety Statements:26-36-24/25
Useful
● Canonical SMILES: C1=CC(=CC=C1C(C(=O)O)N)O
● Isomeric SMILES: C1=CC(=CC=C1[C@H](C(=O)O)N)O
● Uses: 4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics. 4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.
Detailed Introduction
4-Hydroxy-D-phenylglycine, also known as 4-hydroxy-D-phenylglycine or 4-HDPG, is a chemical compound with the molecular formula C8H9NO3. It is an amino acid derivative and belongs to the category of phenylglycines.4-Hydroxy-D-phenylglycine is primarily used as a building block in the synthesis of pharmaceutical compounds. It serves as a raw material in the production of certain antibiotics, such as cefadroxil and cephradine. These antibiotics belong to the cephalosporin class and are used to treat bacterial infections.In addition to its role as a precursor in pharmaceutical synthesis, 4-Hydroxy-D-phenylglycine has also been investigated for its potential therapeutic properties. Research suggests that it may have antioxidant and anti-inflammatory effects, which could make it useful in the development of new drugs for various medical conditions.Overall, 4-Hydroxy-D-phenylglycine is a chemical compound with important applications in pharmaceutical synthesis and potential therapeutic uses. Its role as a building block in the production of antibiotics highlights its significance in the pharmaceutical industry.
