4-Hydroxy-D-(-)-2-phenylglycine

Short Description:

Product Name: 4-Hydroxy-D-(-)-2-phenylglycine

Synonyms: 4-HYDROXY-D-PHENYLGLYCINE;(R)-(-)-AMINO(4-HYDROXYPHENYL)ACETIC ACID;(R)-AMINO-(4-HYDROXY-PHENYL)-ACETIC ACID;(r)-alpha-amino-4-hydroxybenzeneacetic acid;(R)-ALPHA-AMINO-4-HYDROXYPHENYLACETIC ACID;(R)-4-HYDROXYPHENYLGLYCINE;(R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE;D-(-)-2-(4-HYDROXYPHENYL)GLYCINE

CAS: 22818-40-2

MF: C8H9NO3

MW: 167.16

EINECS: 245-247-7

Product Categories: Antidote / Antibiotic / Antimicrobial;Miscellaneous Biochemicals;Amino ACIDS SERIES;Cephalosporins;Peptide Synthesis;Phenylglycine Derivatives;Pharmaceutical Intermediates;Unnatural Amino Acid Derivatives;Odevixibat

Mol File: 22818-40-2.mol

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Phenylglycine Chemical Properties

Melting point	240 °C (dec.)(lit.)
alpha	-156 º (c=1, 1 N HCl)
Boiling point	295.73°C (rough estimate)
density	1.396
vapor pressure	0Pa at 25℃
refractive index	-158 ° (C=1, 1mol/L HCl)
storage temp.	2-8°C
solubility	5g/l
pka	2.15±0.10(Predicted)
form	Liquid
color	Clear colorless to yellow
optical activity	[α]23/D 158±3°, c = 1 in 1 M HCl
Water Solubility	5 g/L (20 ºC)
BRN	2210998
LogP	-2.25
CAS DataBase Reference	22818-40-2(CAS DataBase Reference)
EPA Substance Registry System	Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-24/25
WGK Germany	3
TSCA	Yes
HS Code	29225000

Phenylglycine Usage And Synthesis

Chemical Properties	off-white powder
Uses	4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.
Uses	4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.
Definition	ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.
Flammability and Explosibility	Nonflammable
Purification Methods	Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]